Phosphatidylinositol transfer proteins: requirements in phospholipase C signaling and in regulated exocytosis

FEBS Letters

Cockcroft, Shamshad¹ 

[1] Department of Physiology, Rockefeller Building, University College London, University Street, London WC1E 6JJ, UK

关键词: Phosphatidylinositol bisphosphate;    Phospholipase C;    Exocytosis;    Phosphatidylinositol transfer protein;    SEC14;   

DOI  :  10.1016/S0014-5793(97)00414-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phosphatidylinositol transfer proteins (PITP) are abundant cytosolic proteins originally identified because of their ability to act in vitro as specific transporters of phosphatidylinositol or phosphatidylcholine between membranes. However, the cellular function of mammalian PITP has remained enigmatic till recently. Due to the development of reconstitution assays in cytosol-depleted cells, PITP was found to be an essential component for phospholipase C-mediated hydrolysis of PIP₂ and for regulated exocytosis. The exact mechanism how PITP exerts its effects is not known but the PI binding/transfer activity of PITP can partly explain its cellular function. PITP would enable the local synthesis of PIP₂ by delivering PI to specialized signaling sites.

【 授权许可】

Unknown