Rolling in the clover: trefoil factor family (TFF)‐domain peptides, cell migration and cancer

FEBS Letters

Rio, M.-C⁴  Wright, N.A¹  Otto, W.R¹  Hoffmann, W³  Thim, L² 

[1] Histopathology Unit, Imperial Cancer Research Fund, London WC2A 3PX, UK;Department of Protein Chemistry, Novo Nordisk, Bagsvaerd DK-2880, Denmark;Institute for Molecular Biology and Medical Chemistry, University of Magdeburg, Leipziger Strasse 44, Magdeburg D-39120, Germany;INSERM U184, Institut de Génetique et de Biologie Moleculaire et Cellulaire, Université Louis Pasteur, Strasbourg, France

关键词: Trefoil factor family;    TFF-domain peptide;    Cancer;    Cell migration;    Ulcer;    Invasion;    BCEI;    breast cancer estrogen-inducible;    EGF;    epidermal growth factor;    ITF;    intestinal trefoil factor;    SP;    spasmolytic polypeptide;    TFF;    trefoil factor family;   

DOI  :  10.1016/S0014-5793(97)00424-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Trefoil factor family (TFF)-domain peptides 1–3 are mucin-associated molecules, largely found in epithelia of gastro-intestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conférence Philippe Laudat agreed upon a new nomenclature for these peptides.

【 授权许可】

Unknown