The E. coli SRP: preferences of a targeting factor

FEBS Letters

Valent, Quido A¹  Luirink, Joen¹  Von Heijne, Gunnar²  De Gier, Jan-Willem L² 

[1] Department of Microbiology, BioCentrum Amsterdam, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands;Department of Biochemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden

关键词: Escherichia coli;    Protein-targeting;    Signal recognition particle;    Inner membrane protein;    GSP;    general secretory pathway;    SRP;    signal recognition particle;    ER;    endoplasmic reticulum;    Ffh;    Fifty-four homolog;    LacY;    lactose permease;    Lep;    leader peptidase;   

DOI  :  10.1016/S0014-5793(97)00402-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Research on the targeting of proteins to the cytoplasmic membrane of E. coli has mainly focused on the so-called ‘general secretory pathway’ (GSP) which involves the Sec-proteins. Recently, evidence has been obtained for an alternative targeting pathway in E. coli which involves the signal recognition particle (SRP). The constituents of this SRP pathway in E. coli are homologous to those of the well-characterized eukaryotic SRP pathway, which is the main targeting pathway for both proteins translocated across and inserted into the endoplasmic reticulum membrane. However, until recently, no clear function could be assigned to the SRP in E. coli. New studies point to an important role of the E. coli SRP in the assembly of inner membrane proteins.

【 授权许可】

Unknown