Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension

FEBS Letters

Kawamura, Toru¹  Takai, Shinji¹  Koyama, Mamoru¹  Nakamura, Norifumi¹  Miyazaki, Mizuo¹  Shiota, Naotaka¹  Jin, Denan¹ 

[1] Department of Pharmacology of Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569, Japan

关键词: Angiotensin-converting enzyme;    Chymase;    Fibrosis;    Apoptosis;    Pressure overload;   

DOI  :  10.1016/S0014-5793(97)00295-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Chronic pressure overload induces cardiac tissue remodeling. Chymase is known to regulate matrix metabolism and angiotensin II formation. In the present study, we investigated the pathophysiological functions of chymase in the pressure-overloaded hamster heart induced by a two-kidney, one-clip (2K1C) hypertension procedure. Fibrosis and apoptosis were observed in the pressure-overloaded hearts of 2K1C hamsters 32 weeks after clipping, but these histological changes were not detected at 16 weeks. Heart chymase-like activity of 2K1C hamsters at 32 weeks increased 5.2-fold compared with that at 16 weeks, while angiotensin-converting enzyme was not activated. Chymase might be involved in cardiac tissue remodeling during the chronic stage of hypertension.

【 授权许可】

Unknown