Inhibition of chymase reduces vascular proliferation in dog grafted veins

FEBS Letters

Yuda, Atsushi¹  Takai, Shinji²  Nishimoto, Masayoshi¹  Sasaki, Shinjiro¹  Miyazaki, Mizuo²  Jin, Denan²  Sakagichi, Masato² 

[1] Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan;Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan

关键词: Chymase;    Inhibitor;    Angiotensin II;    Angiotensin-converting enzyme;    DFP;    diisopropyl phosphorofluoridate;    EDTA;    ethylenediaminetetraacetic acid;   

DOI  :  10.1016/S0014-5793(00)01125-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We investigated the effect of a chymase inhibitor Suc-Val-Pro-Phe^P(OPh)₂ on the proliferation of the grafted vein in dog. By 28 days after the operation, the mean intimal area of the grafted vein in the placebo group was 3.24±0.32 mm². The intimal area of the grafted vein in the chymase inhibitor-treated group was reduced to 63.9%. In the placebo group, the activities of chymase and angiotensin-converting enzyme in grafted vein were significantly increased 15- and 2-fold, respectively. In the chymase inhibitor-treated group, chymase activity in the grafted veins was decreased significantly. These findings suggest that inhibition of chymase appears useful for preventing vascular proliferation.

【 授权许可】

Unknown