Photoactivation of the nitric oxide donor SIN‐1

FEBS Letters

Oberle, Stefanie¹  Ullrich, Thomas¹  Schröder, Henning¹  Abate, Aida¹ 

[1]Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang-Langenbeck-Str. 4, 06099 Halle (Saale), Germany

关键词: SIN-1;    Linsidomine;    Sodium nitroprusside;    Nitric oxide;    Nitrite;    Photoactivation;    SIN-1;    linsidomine (3-morpholinosydnonimine);    NO;    nitric oxide;   

DOI  :  10.1016/S0014-5793(97)00239-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This study investigates whether nitric oxide (NO) release from linsidomine (SIN-1), the active metabolite of the antianginal drug molsidomine, is light sensitive. A 9-h irradiation with polychromatic visible light increased the formation of nitrite (NO index metabolite) from SIN-1 (1 mM) by 61% as compared to control samples incubated in the dark. Under the same conditions (9-h irradiation) the concentration of oxygen decreased to 2% of control. However, oxygen consumption was substantially reduced when light was excluded (35% recovery after 9 h). These results show that irradiation with visible light markedly enhances the oxygen-dependent NO release from SIN-1. Thus, sydnonimines appear to be suitable model compounds for the development of photoactivatable NO donors.

【 授权许可】

Unknown