The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family

FEBS Letters

Sonoda, Gonosuke²  Bonnert, Timothy P¹  Parnet, Patricia¹  Sims, John E¹  Garka, Kirsten E¹  Testa, Joseph R² 

[1] Immunex Corporation, 51 University Street, Seattle, WA 98101, USA;Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA

关键词: Interleukin 1 receptor;    Death-domain;    Chromosome 3p;    IL-1;    interleukin 1;    IL-6;    interleukin 6;    IL-1R;    type I interleukin 1 receptor;    IL-1Rrp1;    IL-1 receptor related protein 1;    IL-1RAcP;    IL-1 receptor accessory protein;    rsc786;    randomly sequenced cDNA 786;    PCR;    polymerase chain reaction;    TNF;    tumor necrosis factor;   

DOI  :  10.1016/S0014-5793(96)01506-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to ‘death-domains’, is rapidly upregulated during differentiation of the myeloleukemic cell line M1. We have cloned the human homologue of murine MyD88 and re-evaluated the murine sequence. The open reading frame for both species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino acids longer than originally published. Human MyD88 cDNA is encoded by 5 exons, and maps to chromosome 3p21.3-p22 by fluorescence in situ hybridization (FISH). Overexpression of the death domain region leads to transcriptional activation of the IL-8 promoter.

【 授权许可】

Unknown