Two‐chain structure of the interleukin 1 receptor

FEBS Letters

Resch, K.¹  Dayer, J.M.³  Kroggel, Roswitha¹  Pingoud, Vera²  Martin, M.¹ 

[1] Division of Pharmacology, Medical School Hannover, Konstanty-Gutschow-Str. 8, D-3000 Hannover 61, FRG;Division of Biochemistry, Medical School Hannover, Konstanty-Gutschow-Str. 8, D-3000 Hannover 61, FRG;Division of Immunology and Allergy (Hans Wilsdorf Laboratory), Department of Medicine, University Hospital, 1211 Geneva 4, Switzerland

关键词: Interleukin 1 receptor;    Recombinant interleukin 1;    Cross-linking;   

DOI  :  10.1016/0014-5793(88)80797-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

By crosslinking radioiodinated recombinant human IL1 α to mouse EL4 thymoma cells we have identified in addition to the known IL1-binding proteins of 80 kDa, a second IL1-binding protein of about 40 kDa. This second binding protein could be demonstrated most easily when crosslinking to higher protein complexes was inhibited. This finding suggests that the IL1 receptor, similar to the receptor for other cytokines such as interleukin 2, is composed of a heterodimer, of which both polypeptides contribute to ligand binding.

【 授权许可】

Unknown