Cloning, expression and CNS distribution of Kv4.3, an A‐type K+ channel α subunit

FEBS Letters

Chou, Chaio-Chaio³  Shih, Yang-Hsin²  Tsaur, Meei-Ling³  Wang, Hung-Li¹ 

[1] Department of Physiology, Chang Gung College of Medicine and Technology, Tao-Yuan 333, Taiwan, ROC;Division of Neurosurgery, Neurological Institute, Veterans General Hospital, Taipei 112, Taiwan, ROC;Institute of Neuroscience, National Yang-Ming University, Taipei 112, Taiwan, ROC

关键词: Voltage-dependent potassium channel;    cDNA cloning;    A-type potassium channel;    Xenopus oocyte;    In situ hybridization;   

DOI  :  10.1016/S0014-5793(96)01388-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A full-length K⁺ channel cDNA of Kv4.3, with an open reading frame of 611 amino acids, was isolated from rat hippocampus. Functional expression of Kv4.3 cDNA in Xenopus oocytes revealed an A-type K⁺ channel. In the central nervous system, Kv4.3 is most prominently expressed in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum, as well as lateral geniculate and superior colliculus, which are important for vision. The abundant expression of Kv4.3 in many CNS neurons supports its important role as a major component of subthreshold A currents in the control of action potentials and thus neuronal excitability.

【 授权许可】

Unknown