Troglitazone inhibits angiotensin II‐induced DNA synthesis and migration in vascular smooth muscle cells

FEBS Letters

Xi, Xiao-Ping¹  Law, Ronald E¹  Graf, Kristof¹  Hsueh, Willa A¹ 

[1] University of Southern California, School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Los Angeles, CA 90033, USA

关键词: Angiotensin II;    DNA synthesis;    MAP kinase;    Migration;    Smooth muscle cell;    Troglitazone;   

DOI  :  10.1016/S0014-5793(96)01371-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Angiotensin II (AII) plays a crucial role in controlling the proliferation and migration of vascular smooth muscle cells (VSMCs). The present study was undertaken to determine if troglitazone (Tro) has an effect on the G-protein coupled signaling through AII type I (AT-1) receptors in cultured rat aortic VSMCs. AII-induced MAP kinase activation was inhibited 67.9% by Tro. AII-induced DNA synthesis and migration was completely inhibited by Tro or by the AT-1 receptor blocker irbesartan. The present study demonstrates that troglitazone inhibits AII-induced DNA synthesis, migration and MAP kinase activation in VSMCs which are important molecular events for the development of neointimal hyperplasia and atherosclerosis.

【 授权许可】

Unknown