c‐Fos transrepression revisited

FEBS Letters

Cahill, Michael A¹ 

[1] Transcriptional Regulation Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT, Australia

关键词: Transcription regulation;    Transcription factor;    Transcription coactivator;    Fos;    AP-1;   

DOI  :  10.1016/S0014-5793(96)01349-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The c-fos proto-oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c-Fos protein led to deregulated growth control, and c-Fos was thought to be so critically involved in cell cycle control that transcriptional transrepression of its own promoter was interpreted as a negative feedback mechanism. However, recent findings render this conclusion improbable, Fos transrepression being most parsimoniously explained as transcriptional squelching imposed by artificially elevated levels of exogenous Fos protein.

【 授权许可】

Unknown