Regulatory squelching

FEBS Letters

Ernst, Wolfram H.¹  Janknecht, Ralf¹  Cahill, Michael A.¹  Nordheim, Alfred¹ 

[1] Medizinische Hochschule Hannover, Institut für Molekularbiologie, D-30623 Hannover, Germany

关键词: Transcription regulation;    Transcription factor;   

DOI  :  10.1016/0014-5793(94)00320-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be more important than hitherto appreciated.

【 授权许可】

Unknown