The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance

FEBS Letters

Miyakawa, Tokichi¹  Hirata, Dai¹  Mizunuma, Masaki¹  Miyahara, Kohji¹  Tsuchiya, Eiko¹ 

[1] Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Higashi-Hiroshima 739, Japan

关键词: ABC transporter;    Multidrug resistance;    Sodium;    Lithium;    Manganese;    Saccharomyces cerevisiae;   

DOI  :  10.1016/S0014-5793(96)01353-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ATP-binding cassette superfamily proteins Pdr5p and Snq2p of Saccharomyces cerevisiae are implicated in multidrug resistance. Here, we show that these transporters are also involved in cation resistance. Null mutants of PDR5 and SNQ2 genes exhibit increased sensitivity to NaCl, LiCl and MnCl₂. The mutant cells grown in the presence of high concentrations of these metal salts contain higher levels of the metals than wild-type cells. The expression of PDR5 and SNQ2 is induced by the metal salts. These results provide evidence that the yeast drug transporters contribute to cation resistance by regulating cellular cation homeostasis under ionic stress conditions.

【 授权许可】

Unknown