Synergistic effects of transforming growth factor‐β on the expression of c‐fms, macrophage colony‐stimulating factor receptor gene, in vascular smooth muscle cells

FEBS Letters

Yagyu, Hiroaki¹  Yazaki, Yoshio¹  Inaba, Toshimori¹  Harada, Kenji¹  Ohashi, Ken¹  Ishibashi, Shun¹  Osuga, Jun-ichi¹  Yamada, Nobuhiro¹ 

[1] The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

关键词: Vascular smooth muscle cell;    Atherosclerosis;    Macrophage colony-stimulating factor;    Transforming growth Factor-β;    Platelet-derived growth factor;   

DOI  :  10.1016/S0014-5793(96)01322-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vascular smooth muscle cells (SMC) transform to foam cells in the process of atherosclerosis. We have reported that SMC derived from the intima of atherosclerotic lesions express c-fms, macrophage colony-stimulating factor receptor gene, which is not normally expressed in medial SMC. In the present study, we demonstrated that transforming growth factor-β (TGF-β) synergistically induced expression of c-fms in the presence of platelet-derived growth factor-BB in human medial SMC, a level comparable to that observed in the intima. The induction of c-fms was not inhibited by protein kinase C (PKC) inhibitor, suggesting that TGF-β induces c-fms via a PKC-independent pathway. These results suggest that TGF-β plays an important role in the phenotypic change of smooth muscle cells to macrophage-like cells in the process of atherosclerosis.

【 授权许可】

Unknown