Molecular cloning, expression and tissue distribution of a chicken angiotensin II receptor

FEBS Letters

Gasc, Jean-Marie²  Moullec, Jean-Michel le¹  Corvol, Pierre²  Kempf, Hervé² 

[1] Roussel-UCLAF, 93230 Romainville, France;Collège de France and INSERM U36, 3 rue d'Ulm, 75005 Paris, France

关键词: Angiotensin II receptor;    Molecular cloning;    Gallus domesticus;    Ang;    angiotensin;    Sar;    sarcosine;    AT receptor;    angiotensin receptor;    tAT;    turkey angiotensin receptor;    cAT;    chicken angiotensin receptor;    RAS;    renin-angiotensin system;   

DOI  :  10.1016/S0014-5793(96)01264-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA encoding a chicken angiotensin II receptor from adrenal gland was isolated to serve as a molecular tool to study the role of AngII in avian embryonic development. This cDNA, sharing a high homology with another avian receptor (turkey), encodes a protein of 359 amino acids with 75% sequence identity with the mammalian type 1 receptor. Transient xpression has revealed pharmacological properties distinct from mammalian receptors and a functional coupling leading to the increase in inositol phosphate production. The AngII receptor mRNA is expressed in classical target organs for AngII (adrenal gland, heart, kidney) and, interestingly, in endothelial cells where it may mediate the peculiar vasorelaxation effect of AngII in the chicken.

【 授权许可】

Unknown