Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes

FEBS Letters

Ermak, Gennady¹  Pawelek, John²  Chakraborty, Ashok²  Slominski, Andrzej¹  Baker, James¹ 

[1] Department of Pathology and Laboratory Medicine, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA;Department of Dermatology, Yale University, New Haven, CT 06520, USA

关键词: Corticotropin releasing factor;    Ultraviolet B;    Melanocyte;    Skin;    Environmental stress;   

DOI  :  10.1016/S0014-5793(96)01315-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Here we show that human melanocytes express the corticotropin releasing factor (CRF) gene and produce CRF peptide. The CRF production and secretion is markedly stimulated by ultraviolet B (UVB) radiation. This is the first demonstration that cutaneous melanocytes respond to environmental stress (UVB) through the production of CRF.

【 授权许可】

Unknown