Regulation of Mg2+ homeostasis by insulin in perfused rat livers and isolated hepatocytes

FEBS Letters

Scarpa, Antonio¹  Keenan, Donald¹  Romani, Andrea¹ 

[1] Departments of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 2109 Abington Road, Cleveland, OH 44106-4907, USA

关键词: Mg2+;    β-Adrenergic receptor;    Insulin;    Liver;    cAMP;   

DOI  :  10.1016/0014-5793(96)01051-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several recent studies demonstrate that adrenergic receptor stimulation evokes marked changes in Mg²⁺ homeostasis. As insulin counter-regulates many of the metabolic consequences of adrenergic receptor stimulation, we evaluated the potential influence of insulin on Mg²⁺ movements in response to adrenergic stimulation. The data demonstrate that insulin is able to block the Mg²⁺ efflux from perfused rat livers stimulated by isoproterenol or 8-Br-cAMP, but has little or no effect on epinephrine or phenylephrine induced Mg²⁺ efflux. Thus, evidence is provided demonstrating that there are redundant adrenergic pathways regulating Mg²⁺ efflux from liver tissue. One of these pathways, the β-adrenergic component, is selectively blocked by insulin. Furthermore, these findings may provide a cellular explanation for hypomagnesemia associated with diabetes.

【 授权许可】

Unknown