Acute meal‐induced changes in hepatic glycerolipid metabolism are unimpaired in severely diabetic rats: implications for the role of insulin

FEBS Letters

Moir, Alison M.B.¹  Zammit, Victor A.¹ 

[1] Hannah Research Institute, Ayr, KA6 5HL, Scotland, UK

关键词: Insulin;    Liver;    ApoB;    Cell volume;    Secretion;   

DOI  :  10.1016/0014-5793(95)00838-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of food intake on the partitioning of diacylglycerol between phospholipid and triacylglycerol synthesis, and on the fractional rate of secretion of triacylglycerol was studied in starved-refed diabetic rats by using the technique of selective labelling of hepatic fatty acids in vivo. Acute and phasic responses in these parameters similar to those observed previously in normal animals were obtained, in spite of the absence of any insulin response to refeeding. Labelling of the major phospholipids (phosphatidylcholine and phosphatidylethanolamine) increased markedly at the expense of triacylglycerol labelling. In addition, the fractional rate of secretion of newly-labelled triacylglycerol was decreased. The data suggest that insulin is not obligatorily involved in any decreases in hepatic triacylglycerol secretion in the prandial period, but that it may act synergistically with other meal-induced signals to mediate this effect in normal animals.

【 授权许可】

Unknown