Cell volume is a major determinant of proteolysis control in liver

FEBS Letters

Häussinger, Dieter²  Schweizer, Ursula²  Decker, Sheila²  Gerok, Wolfgang²  Lang, Florian¹  Hallbrucker, Christian²  vom Dahl, Stephan² 

[1] Physiologisches Institut der Universität Innsbruck, Austria;Medizinische Universitätsklinik Freiburg, Germany

关键词: Glucagon;    Insulin;    Proteolysis;    Perfused liver;    Cell volume;    Hormone action;    Intracellular water space;    Glutamine;    Glycine;    Cyclic AMP;    Bumetanide;   

DOI  :  10.1016/0014-5793(91)80556-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Hepatic proteolysis is inhibited by insulin, amino acids and hypoosmotic cell swelling and is stimulated by glucagon. These effectors simultaneously modulate cell volume in the intact liver, as shown by measurements of the intracellular water space. A close relationship exists between the effect on proteolysis and the accompanying cell volume change, regardless of whether hepatic proteolysis was modified by insulin, glucagon, cyclic AMP, glutamine, glycine, barium of hypoosmotic exposure. It is suggested that cell volume changes exerted by hormones and amino acids play a crucial role in the regulation of hepatic proteolysis.

【 授权许可】

Unknown