Sequence analysis and distribution of two new human cathepsin L splice variants

FEBS Letters

Rescheleit, Dietmar K.¹  Rommerskirch, Winfried J.¹  Wiederanders, Bernd¹ 

[1] Friedrich-Schiller-Universität Jena, Klinikum, Institut für Biochemie, Löbder Straße 3, 07740 Jena, Germany

关键词: Cathepsin L;    Alternative splicing;    5′ UTR stem loop;    Post-transcriptional control;    Tumor;   

DOI  :  10.1016/0014-5793(96)00986-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Despite elevated cathepsin L mRNA levels in kidney tumors, cathepsin L protein/activity was scarcely detectable in these tumors. As a possible reason, we detected two new splice variants of human cathepsin L mRNAs not identical to those previously reported. Besides the normal ‘full-length’ mRNA (hCATL-A) there is one form lacking 27 nucleotides (hCATL-A I) and another form lacking 90 nucleotides (hCATL-A II) in exon I. The splice variants do not influence the amino acid sequence of the translational product. hCATL-A and hCATL-A I probably form a secondary structure at the 5′ non-coding sequence not present in hCATL-A II.

【 授权许可】

Unknown