Correlation of intrinsic DNA curvature with DNA property periodicity

FEBS Letters

Gabrielian, Andrei¹  Pongor, Sándor¹ 

[1] International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park, Padriciano 99, 34012 Trieste, Italy

关键词: DNA structure;    DNA curvature;    Sequence periodicity;    Fourier analysis;   

DOI  :  10.1016/0014-5793(96)00855-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Twelve di- and trinucleotide parameter sets representing various structural, thermodynamic or bendability-related properties of DNA were tested in the prediction of DNA curvature applying Fourier analysis on curved and straight, A/T-type or G/C-type DNA sequence motifs. The best predictions were obtained with a new consensus bendability scale created by combining a nucleosome-based and a deoxyribonuclease I-based parameter set. Geometry calculations on the same sequences showed that the helical parameters derived from NMR structures can correctly predict curvature, as distinct from the parameters derived from X-ray crystallographic analysis.

【 授权许可】

Unknown