Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte‐macrophages

FEBS Letters

Esterbauer, Hermann²  Marchant, Christine E.¹  Law, Nadine S.¹  Müller, Karin¹  Carpenter, Keri L.H.¹  Hardwick, Simon J.¹  Waeg, Georg²  Mitchinson, Malcolm J.¹ 

[1] Division of Cellular Pathology, University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK;Institute of Biochemistry, University of Graz, Schubertstrasse 1, A-8010 Graz, Austria

关键词: Aldehydes;    Cytotoxicity;    Chemotaxis;    Monocyte-macrophage (human);    Oxidised LDL;    Atherosclerosis;   

DOI  :  10.1016/0014-5793(96)00559-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the cytotoxic and chemotactic potencies of malondialdehyde (MDA), hexanal, 4-hydroxyhexenal (HHE), 4-hydroxynonenal (HNE) and 4-hydroxyoctenal (HOE), which are aldehydes found in oxidised low density lipoprotein (LDL), for human monocyte-macrophages. They were toxic in the following order: hexanal < HHE = HOE < HNE. HNE was toxic at 20 μM and chemotactic at 2.5 μM. The other aldehydes tested had no chemoattractant activity. Our results suggest that HNE arising from LDL oxidation could attract monocytes into the human atherosclerotic lesion. A direct cytotoxic role of aldehydes in foam cell death in the lesion is less likely.

【 授权许可】

Unknown