SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

FEBS Letters

Mertens, Stephan¹  Craxton, Molly¹  Goedert, Michel¹ 

[1]MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

关键词: Mitogen-activated protein kinase;    Stress-activated protein kinase;    Stress-activated protein kinase-3;    HOG1;   

DOI  :  10.1016/0014-5793(96)00255-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Stress-activated protein kinases are MAP kinase homologues that are activated by cellular stresses, bacterial endotoxin and inflammatory cytokines. They are activated by a dual threonine/tyrosine phosphorylation within a TPY sequence in the case of stress-activated protein kinase-1 and its isoforms (also called JNKs) or a TGY sequence in the case of stress-activated protein kinase-2 and its isoforms (also called p38, p40, RK, CSBPs, XMpk2 and Mxi2). Here we report the cloning and sequencing of a new protein kinase from rat with a TGY sequence in the activation domain. This stress-activated protein kinase-3 is 60% identical to mouse stress-activated protein kinase-2 and 45% identical to HOG1 from Saccharomyces cerevisiae. Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle.

【 授权许可】

Unknown