Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up‐regulated during postnatal mouse cerebral development

FEBS Letters

Watanabe, Norinobu M.¹  Matsumoto, Kunihiro¹  Nakashima, Takashi M.¹  Ninomiya-Tsuji, Jun¹  Dan, Ippeita²  Kobayashi, Takeshi²  Kajikawa, Eriko²  Fukagaya, Yukiko²  Kimura, Wataru K.¹  Kusumi, Akihiro²  Yamashita-Suzuki, Kaoru² 

[1]Department of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

[2]Kusumi Membrane Organizer Project, ERATO, JST, 5-11-33 Chiyoda, Nagoya 460-0012, Japan

关键词: Misshapen/NIKs-related kinase;    Signal transduction;    Germinal center kinase family kinase;    Mitogen-activated protein kinase;    Stress-activated protein kinase;   

DOI  :  10.1016/S0014-5793(00)01247-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways.

【 授权许可】

Unknown