The 170 kDa glucose regulated stress protein is a large HSP70‐ HSP110‐like protein of the endoplasmic reticulum

FEBS Letters

Oh, Hyun-Ju¹  Lee-Yoon, Dong-Sin¹  Chen, Xing¹  Subjeck, John¹  Easton, Douglas²  Liu, Xiaoguang¹ 

[1] Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA;Department of Biology, State University of New York College, Buffalo, NY 14222, USA

关键词: Heat shock protein;    Glucose regulated protein;    Anoxia;   

DOI  :  10.1016/0014-5793(96)00011-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The existence of a family of unusually large and highly diverged hsp70-like proteins (the hsp110/SSE family) has recently been described. The 170 kDa glucose regulated stress protein (grp170) is a retained endoplasmic reticulum glycoprotein that may be involved in immunoglobulin folding and/or assembly. We describe here the cloning of the cDNA for grp170 and show that it, like hsp110, is a large and highly diverged hsp70-like polypeptide which shares specific features with hsp70 (the dnaK family) and the hsp110/SSE family, while also differing from both. Grp170 contains an ATP binding domain and binds ATP, it possesses a carboxyl terminal NDEL sequence, and its mRNA is anoxia inducible.

【 授权许可】

Unknown