Sequence‐specific DNA binding activity of rat cdc37‐related gene product

FEBS Letters

Ozaki, Toshinori¹  Sakiyama, Shigeru¹ 

[1] Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2, Nitona, Chuou-ku, Chiba 260, Japan

关键词: Basic/leucine zipper;    Cdc37;    Cell cycle;    3Y1 cells;   

DOI  :  10.1016/0014-5793(95)01210-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The rat cdc37-related gene product (RCdc37), which is possibly involved in the regulation of cell cycle progression, contains a putative basic/leucine zipper (bZIP) domain in its N-terminal portion. In this study, we have identified a rat genomic sequence which can interact with RCdc37 using an in vitro binding assay. The specificity of this interaction was confirmed by gel retardation experiments. These results raise a possibility that RCdc37 might play an important role in the control of cell cycle progression via a sequence-specific DNA binding mechanism.

【 授权许可】

Unknown