The expression of the imprinted H19 and IGF‐2 genes in human bladder carcinoma

FEBS Letters

Cooper, Mark⁵  Hochberg, A.⁶  Kopf, Eliezer³  Elkin, Michael⁶  Ariel, Ilana⁴  Schulze, Ekkehard¹  Shevelev, Alexander¹  Tykocinsky, Mark¹  Pode, Dov²  de Groot, Nathan⁶ 

[1] Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA;Department of Urology, Hadassah University Hospital, Ein-Karem, Jerusalem, Israel;Department of Biochemistry, Weizmann Institute of Science, Rehovot, Israel;Department of Pathology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel;Department of Medicine, Case Western Reserve University, Cleveland, OH, USA;Department of Biological Chemistry, The Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel

关键词: Genomic imprinting;    Bladder carcinoma;    H19;    IGF-2;    Mono-allelic expression;    Bi-allelic expression;    IGF-2;    insulin-like growth factor II gene;    IPW;    imprinted gene in the Prader-Willi syndrome region;    GAPDH;    glyceraldehyde-3-phosphate dehydrogenase;   

DOI  :  10.1016/0014-5793(95)01074-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.

【 授权许可】

Unknown