Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility

Genetics and Molecular Biology

Yao-yuan Hsieh²  Chi-chen Chang²  Fuu-jen Tsai¹  Ching-tien Peng¹  Lian-shun Yeh²  Cheng-chieh Lin¹ 

[1] ,China Medical University Hospital Department of Obstetrics and Gynecology Taichung,Taiwan

关键词: endometriosis;    insulin-like growth factor;    IGF-2;   

DOI  :  10.1590/S1415-47572004000200006

来源: SciELO

【 摘 要 】

Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License