Multiple gene products are produced from a novel protein kinase transcription region

FEBS Letters

Martin Watterson, D³  Lukas, Thomas J³  Birukov, Konstantin G²  Collinge, Mark³  Van Eldik, Linda J¹  Shirinsky, Vladimir P³  Stepanova, Olga V² 

[1]Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, IL 60611-3008, USA

[2]Cardiology Research Center, Russian Academy of Medical Sciences, 3-rd Cherepkovskaya Str. 15a., Moscow 121552, Russian Federation

[3]Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, IL 60611-3008, USA

关键词: Gene expression;    Amino acid sequence;    Protein kinase;    Myosin;    Calmodulin;    CEF;    chicken embryo fibroblasts;    KRP;    kinase related protein;    MLCK;    myosin light chain kinase;   

DOI  :  10.1016/0014-5793(95)01048-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nonmuscle/smooth muscle myosin light chain kinase (MLCK) and the kinase related protein (KRP) that lacks protein kinase activity are myosin II binding proteins encoded in the vertebrate genome by a true gene within a gene relationship. The genomic organization and expression result in the same amino acid sequence in different molecular contexts from two different sizes of mRNA. We report here the identification and characterization of a third size class of gene products. The protein appears to be a higher molecular weight form of MLCK with additional amino terminal tail sequence which might provide differential subcellular targeting characteristics.

【 授权许可】

Unknown