Three‐dimensional architecture of the skeletal muscle ryanodine receptor

FEBS Letters

Radermacher, Michael¹  Wagenknecht, Terence¹ 

[1] Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany, New York 12201-0509, USA

关键词: Ryanodine receptor;    Calcium release;    Cryo-electron microscopy;    Three-dimensional reconstruction;    Excitation-contraction;    Muscle;    Image processing;   

DOI  :  10.1016/0014-5793(95)00581-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent advances in determining the three-dimensional architecture of the skeletal muscle ryanodine receptor/calcium release channel (RyR) by cryo-electron microscopy and three-dimensional reconstruction are discussed. The tetrameric receptor is characterized by a large 4-fold symmetric cytoplasmic assembly that consists of many domains separated by solvent-containing crevices and holes. Experimental evidence suggests that at least one regulatory ligand, calmodulin, binds to sites on the cytoplasmic assembly that are at least 10 nanometers from the transmembrane channel.

【 授权许可】

Unknown