Involvement of the brain type of ryanodine receptor in T‐cell proliferation

FEBS Letters

Imoto, Keiji¹  Nakai, Junichi¹  Hakamata, Yasuhiro²  Kita, Toru²  Nakashima, Yasuyo²  Nishimura, Seiichiro² 

[1] Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan;Department of Geriatric Medicine, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan

关键词: Ryanodine receptor;    cDNA cloning;    Calcium release;    Cell proliferation;    FK506;    Jurkat T-lymphocyte;    RYR;    ryanodine receptor;    CICR;    calcium-induced calcium release;    FKBP;    FK506-binding protein;    [Ca2+]i;    intracellular calcium concentration;   

DOI  :  10.1016/0014-5793(94)00955-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca²⁺ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

【 授权许可】

Unknown