期刊论文详细信息
FEBS Letters | |
Involvement of the brain type of ryanodine receptor in T‐cell proliferation | |
Imoto, Keiji1  Nakai, Junichi1  Hakamata, Yasuhiro2  Kita, Toru2  Nakashima, Yasuyo2  Nishimura, Seiichiro2  | |
[1] Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan;Department of Geriatric Medicine, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan | |
关键词: Ryanodine receptor; cDNA cloning; Calcium release; Cell proliferation; FK506; Jurkat T-lymphocyte; RYR; ryanodine receptor; CICR; calcium-induced calcium release; FKBP; FK506-binding protein; [Ca2+]i; intracellular calcium concentration; | |
DOI : 10.1016/0014-5793(94)00955-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.
【 授权许可】
Unknown
【 预 览 】
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