hBD‐1: a novel β‐defensin from human plasma

FEBS Letters

Mägert, Hans-Jürgen¹  Forssmann, Wolf-Georg¹  Bensch, Klaus W.¹  Raida, Manfred¹  Schulz-Knappe, Peter¹ 

[1] Niedersächsisches Institut für Peptid-Forschung, Feodor-Lynen Str. 31 ,D-30625 Hannover, Germany

关键词: β-Defensin;    Antimicrobial peptide;    Hemofiltrate;    Amino acid sequence;    cDNA;   

DOI  :  10.1016/0014-5793(95)00687-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report the isolation and characterization of a novel peptide with significant sequence homology to β-defensins from human blood filtrate. The human β-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for β-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.

【 授权许可】

Unknown