PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases

FEBS Letters

Domdey, H.¹  Stumpf, G.¹  Hani, J.¹ 

[1] Genzentrum der Ludwig-Maximilians-Universität Müchen, Würmtalstraße 221, D-81375 München, Germany

关键词: Peptidyl-prolyl cis/trans isomerase;    Nucleotide sequence;    Sequence homology;    Saccharomyces cerevisiae;   

DOI  :  10.1016/0014-5793(95)00471-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Complementation of a temperature sensitive mutant of the yeast Saccharomyces cerevisiae resulted in the isolation of PTF1 (processing/termination factor 1), an essential gene encoding a putative 3′-end processing or transcription termination factor of pre-mRNAs. Ptf1p shows significant homology to a newly discovered family of PPIases. This family is characterized by its insensitivity to immunosuppressive drugs and the lack of homology with cyclophilins and FK-506 binding proteins [Rahfeld et al. (1994) FEBS Lett. 352, 180–184]. Should Ptf1p display PPIase activity, it would be the first characterized, eukaryotic member of this putative family, which is essential for growth.

【 授权许可】

Unknown