Characterization and ultrastructural localization of annexin VI from mitochondria

FEBS Letters

Rainteau, Dominique²  Weinman, Serge²  Rochat, Hervé¹  Mansuelle, Pascal¹ 

[1] Laboratoire de Biochimie, URA CNRS 1455, Faculté de Médecine Nord, 13916 Marseille cedex 20, France;Département de Biochimie, UFR Biomédicale des Saints-Pères, Université René Descartes, 45 rue des Saints-Pères, 75270 Paris cedex 06, France

关键词: Annexin VI;    Mitochondria;   

DOI  :  10.1016/0014-5793(95)00087-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Annexin VI, a member of a family of related intracellular proteins that associate reversibly with membrane phospholipids in a Ca²⁺-dependent manner, has been purified from bovine liver mitochondria and characterized. Moreover, biochemical and immunocytochemical lines of evidence are presented which strongly suggest that annexin VI is closely associated with the cristae in the inner membrane of mitochondria. These findings are consistent with a calcium channel activity of annexin VI in mitochondria.

【 授权许可】

Unknown