The rsp5‐domain is shared by proteins of diverse functions

FEBS Letters

Bucher, Philipp¹  Hofmann, Kay¹ 

[1] Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges s/Lausanne, Switzerland

关键词: Sequence analysis;    Signal transduction;    Dystrophin;    C2-domain;    yap65;    WW-domain;   

DOI  :  10.1016/0014-5793(94)01415-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel, unusually small, and highly conserved domain of modular intracellular proteins is described. The domain was first recognized as three repeats in the yeast rsp5 gene product and named thereafter. The rsp5 protein is thought to interact with nuclear proteins but also contains a C2 domain typical for cytoplasmic proteins. Further analyses revealed several additional occurrences of this domain in diverse protein classes, including cytoplasmic signal transduction proteins, gene products interacting with the transcription machinery, structural proteins like dystrophin, and a putative RNA helicase.

【 授权许可】

Unknown