N‐copine: a novel two C2‐domain‐containing protein with neuronal activity‐regulated expression

FEBS Letters

Yaoi, Takeshi¹  Kuwajima, Goro¹  Yasui, Mitsuru²  Nakayama, Takashi¹ 

[1] CNS Research Laboratories, Shionogi and Co., Ltd., 2-5-1 Mishima, Settsu-shi, Osaka 566-0022, Japan;CNS Research Laboratories, Shionogi and Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

关键词: N-copine;    C2-domain;    Gene expression;    Kainate;    Hippocampus;    Plasticity;    Long-term potentiation;   

DOI  :  10.1016/S0014-5793(98)00497-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Neuronal activity is often associated with changes in gene expression. By a two-dimensional cDNA-display system, restriction landmark cDNA scanning, we identified a novel gene whose expression in the hippocampus was up-regulated by kainate stimulation. The mRNA expression was detected only in brain and up-regulated by the stimulation evoking CA3-CA1 long-term potentiation. The encoded protein contains two copies of C2-domain, known as the Ca²⁺-binding domain of PKC-γ, and shows 49% identity with human copine I. We designated this protein N-copine (neuronal-copine). N-copine may have a role in synaptic plasticity.

【 授权许可】

Unknown