Down‐regulation of phospholipase C‐γ1 during the differentiation of U937 cells

FEBS Letters

Min, Do Sik²  Baek, Suk Hwan²  Ryu, Sung Ho²  Lee, He Jin²  Suh, Pann-Ghill²  Kim, Yong Sik¹  Lee, Seung-Jae²  Lee, Young Han² 

[1] Department of Psychiatry, Seoul National University College of Medicine, Seoul 110-799, South Korea;Department of Life Science, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyung-Buk 790-784, South Korea

关键词: Differentiation;    PMA;    Phospholipase C-γ1;    Phospholipase C-γ2;    Down-regulation;    U937 cell;   

DOI  :  10.1016/0014-5793(94)01404-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.

【 授权许可】

Unknown