Germinating conidiospores of Aspergillus amino acid auxotrophs are hypersensitive to heat shock, oxidative stress and DNA damage

FEBS Letters

McCullough, W.²  Barnett, Y.A.¹  Donnelly, E.² 

[1] Department of Biological and Biomedical Sciences, University of Ulster, Coleraine, Co. Londonderry, BT52 1SA, N. Ireland, UK;Department of Biological and Biomedical Sciences, University of Ulster, Jordanstown, Newtownabbey, Co. Antrim, BT37 0QB, N. Ireland, UK

关键词: DNA repair;    Heat shock;    Oxidative stress;    Cancer;    cAMP/RAS;    Aspergillus nidulans;   

DOI  :  10.1016/0014-5793(94)01207-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Germinating conidiospores (conidia) of Aspergillus nidulans amino acid-requiring strains are hypersensitive to heat, oxidative stress, UV radiation and chemical mutagens when compared with other strains. They also showed an increased mutation rate. Sensitivity to stress conditions has been correlated with an abnormal RAS/cAMP pathway in mutants of S. cerevisiae. We suggest that the RAS/cAMP pathway is defective in germinating conidia of Aspergillus amino acid auxotrophs and that this is responsible for suppressing DNA repair and conferring sensitivity to oxidative stress and heat shock.

【 授权许可】

Unknown