The human serotonin 5‐HT2B receptor: Pharmacological link between 5‐HT2 and 5‐HT1D receptors

FEBS Letters

Maroteaux, Luc²  Choi, Doo-Sup²  Birraux, Guillaume¹  Launay, Jean-Marie¹ 

[1] Hôpital St. Louis, Service de Biochimie, FRA C. Bernard, Unité de Neurochimie des Communications Cellulaires, 1 av C. Vellefaux, 75475 Paris Cedex 10, France;Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U184 de Génétique et de Biologie Moléculaire de l'INSERM, Faculté de Médecine de Strasbourg, 11 rue Humann, 67085 Strasbourg Cedex, France

关键词: G protein-coupled receptor;    cDNA cloning;    Polymerase chain reaction;    Cardiovascular system;    DOI binding;   

DOI  :  10.1016/0014-5793(94)00968-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The human serotonin 5-HT2B receptor, isolated from a human liver cDNA library, was transfected in COS-1 cells. Its pharmacological profile shows divergence with serotonin 5-HT2B receptors of other species. In particular, although strong correlation is observed between the human and the rat 5-HT2B receptor pharmacology, the correlation is almost as significant for the mouse 5-HT2B and the human 5-HT1D receptor agonists. The major sites of expression of its mRNA are in the human liver and kidney, with detectable expression in lung and heart. Therefore, this human 5-HT2B receptor could account for functions attributed to the peripheral 5-HT1D/5-HT2-like receptors, especially in the cardiovascular system. Thus, its detailed original pharmacology is of prime importance for therapeutic drug development.

【 授权许可】

Unknown