期刊论文详细信息
FEBS Letters
Ion channel regulation by calmodulin binding
Kung, Ching1  Saimi, Yoshiro1 
[1] Laboratory of Molecular Biology, Madison, WI, USA
关键词: Ion channel;    Calmodulin;    Ca2+;    Signal transduction;    Channel regulation;   
DOI  :  10.1016/0014-5793(94)00782-9
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

While many ion channels are modulated by phosphorylation, there is growing evidence that they can also be regulated by Ca2+-calmodulin, apparently through direct binding. In some cases, this binding activates channels; in others, it modulates channel activities. These phenomena have been documented in Paramecium, in Drosophila, in vertebrate photoreceptors and olfactory receptors, as well as in ryanodine receptor Ca2+-release channels. Furthermore, studies on calmodulin mutants in Paramecium have shown a clear bipartite distribution of two groups of mutations in the calmodulin gene that lead to opposite behavioral and electrophysiological phenotypes. These results indicate that the N-lobe of calmodulin specifically interacts with one class of ion-channel proteins and the C-lobe with another.

【 授权许可】

Unknown   

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