Ion channel regulation by calmodulin binding

FEBS Letters

Kung, Ching¹  Saimi, Yoshiro¹ 

[1] Laboratory of Molecular Biology, Madison, WI, USA

关键词: Ion channel;    Calmodulin;    Ca2+;    Signal transduction;    Channel regulation;   

DOI  :  10.1016/0014-5793(94)00782-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

While many ion channels are modulated by phosphorylation, there is growing evidence that they can also be regulated by Ca²⁺-calmodulin, apparently through direct binding. In some cases, this binding activates channels; in others, it modulates channel activities. These phenomena have been documented in Paramecium, in Drosophila, in vertebrate photoreceptors and olfactory receptors, as well as in ryanodine receptor Ca²⁺-release channels. Furthermore, studies on calmodulin mutants in Paramecium have shown a clear bipartite distribution of two groups of mutations in the calmodulin gene that lead to opposite behavioral and electrophysiological phenotypes. These results indicate that the N-lobe of calmodulin specifically interacts with one class of ion-channel proteins and the C-lobe with another.

【 授权许可】

Unknown