Interaction of elaiophylin with model bilayer membrane

19th International School on Condensed Matter Physics: Advances in Nanostructured Condensed Matter: Research and Innovations

Genova, J.^1 ; Dencheva-Zarkova, M.^1

Institute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee, Blvd., Sofia

1784, Bulgaria^1

关键词: Bilayer membranes;    Gram-positive bacterium;    Ion channel;    Macrodiolide;    Membrane permeability;    Mode of action;    Patch clamp technique;    Synthetic lipid;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/794/1/012031/pdf
DOI  :  10.1088/1742-6596/794/1/012031

来源: IOP

【 摘 要 】

Elaiophylin is a new macrodiolide antibiotic, which is produced by the Streptomyces strains [1]. It displays biological activities against Gram-positive bacteria and fungi. The mode of action of this antibiotic has been attributed to an alteration of the membrane permeability. When this antibiotic is inserted into the bilayer membranes destabilization of the membrane and formation of ion-penetrable channels is observed. The macrodiolide antibiotic forms stable cation selective ion channels in synthetic lipid bilayer membranes. The aim of this work was to study the interactions of Elaiophylin with model bilayer membranes and to get information on the mechanical properties of lipid bilayers in presence of this antibiotic. Patch-clamp technique [2] were used in the study.