A multifunctional calmodulin‐dependent protein kinase

FEBS Letters

Greengard, Paul²  McGuinness, Teresa L.²  Woodgett, James R.¹  Lai, Yvonne²  Cohen, Philip¹ 

[1] Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland;The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA

关键词: Ca2+;    Calmodulin;    Protein phosphorylation;   

DOI  :  10.1016/0014-5793(83)80846-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca²⁺ in various tissues. Therefore, we propose the name ‘calmodulin-dependent multi-protein kinase’ for this broad specificity enzyme.

【 授权许可】

Unknown