Entry of animal viruses and macromolecules into cells

FEBS Letters

Carrasco, Luis¹ 

[1] Centro de Biologia Molecular and Centro Nacional de Biotecnologia, Universidad Autónoma de Madrid, UAM-CSIC, Cantoblanco, 28049 Madrid, Spain

关键词: Animal virus entry;    Protonmotive force;    Endosome acidification;    Virus receptor;   

DOI  :  10.1016/0014-5793(94)00780-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The entry of animal viruses into cells is mediated by conformational changes in certain virion-particle components. These changes are triggered by the binding of virions to receptors and are influenced by low pH during receptor-mediated endocytosis. These conformational alterations promote the interaction of some viral proteins with cellular membranes thereby leading to transient pore formation and the disruption of ionic and pH gradients. The entry of toxins that do not possess receptors on the cell surface is promoted during the translocation of the virus genome or the nucleocapsid to the cytoplasm. A model is now presented which indicates that efficient virus translocation through cellular membranes requires energy, that may be generated by a protonmotive force. The entry of some animal viruses, as promoted by low pH, should thus only take place when a pH gradient and/or a membrane potential exist, but will not take place if these are dissipated, even if virion particles are present in an acidic enviroment.

【 授权许可】

Unknown