Glucagon‐like peptide 1: A potent glycogenic hormone

FEBS Letters

Delgado, Elena¹  López-Delgado, Maria I.¹  Perea, Almudena¹  Clemente, Felipe¹  Villanueva-Peñacarrillo, Maria L.¹  Morales, Mónica¹  Valverde, Isabel¹ 

[1]Fundación Jiménez Diaz, Departamento de Metabolismo, Nutrición y Hormonas, Avda. Reyes Católicos 2, 28040 Madrid, Spain

关键词: GLP-1;    Hepatic glycogen;    Glycogen-synthase;    cAMP;   

DOI  :  10.1016/0014-5793(94)00699-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

GLP-1(7–36)amide is an insulinotropic peptide derived from the intestinal post-translational proglucagon process, the release of which is increased mainly after a carbohydrate meal; also, its anti-diabetogenic effect in normal and diabetic states has been reported. In this study, GLP-1(7–36)amide stimulates the formation of glycogen from glucose in isolated rat hepatocytes, such a glycogenic effect being achieved with physiological concentrations of the peptide. The GLP-1(7–36)amide-induced glycogenesis is abolished by glucagon, and it is accompanied by stimulation of the glycogen synthase a activity and by a decrease in the basal and glucagon-stimulated cyclic AMP content. These findings could explain, at least in part, the GLP-1(7–36)amide insulin-independent plasma glucose lowering effect.

【 授权许可】

Unknown