Interleukin‐1β activates a short STAT‐3 isoform in clonal insulin‐secreting cells

FEBS Letters

Emilsson, Valur¹  de Groot, Rolf P.²  Cawthorne, Michael A.¹  Morton, Nicholas M.¹ 

[1] Clore Laboratory, The University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK;Department of Pulmonary Diseases, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands

关键词: Interleukin 1β;    Signal transducer and activator of transcription 3;    Clonal β-cell;    Interleukin 1 receptor accessory protein;    IL-1β;    interleukin-1β;    IL-1RI;    interleukin-1 receptor type I;    IL-1RAcP;    interleukin-1 receptor accessory protein;    STAT;    signal transducer and activator of transcription;    JAK;    Janus kinase;    IBMX;    isobutyl methyl xanthine;    GAS;    interferon-γ-activated sequence;    CAT;    chloramphenicol acetyltransferase;    IRE;    interferon-γ/interleukin-6 response element;    ICAM;    intercellular adhesion molecule;    IRF-1;    interferon response factor-1;    SIE;    SIS inducible element;    cAMP;    cyclic adenosine monophosphate;    GLP-1;    glucagon-like peptide 1;   

DOI  :  10.1016/S0014-5793(98)01623-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interleukin-1β (IL-1β) is a potent inflammatory cytokine involved in type 1 diabetes and acts through defined IL-1β signaling pathways. In the present work we describe induction of DNA binding activity to signal transducer and activator of transcription (STAT) in response to IL-1β in clonal insulin-secreting cells. Moreover, IL-1β activates a short isoform of STAT-3 that potently stimulates transcription. Immunoprecipitation studies reveal an interaction between the activated STAT-3 and the IL-1 receptor accessory protein indicating an association between the two signaling pathways. This may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1β in the pancreatic β-cell during the process of type 1 diabetes.

【 授权许可】

Unknown