Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase

FEBS Letters

Gurd, Ruth S.¹  Hoosein, Naseema M.¹ 

[1] Medical Sciences Program and Department of Chemistry, Indiana University, Bloomington, IN 47405, USA

关键词: Glucagon-like peptide I;    Glucagon-like peptide 2;    Glucagon;    cAMP;    Pituitary;    Hypothalamus;    Liver plasma membrane;    GLP-1;    glucagon-like peptide 1;    GLP-2;    glucagon-like peptide 2;   

DOI  :  10.1016/0014-5793(84)81245-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [¹²⁵I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP-1 and GLP-2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30–50 pM concentrations of each peptide elicited half-maximal adenylate cyclase stimulation. Our data suggest that GLP-1 and GLP-2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution.

【 授权许可】

Unknown