FEBS Letters | |
Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase | |
Gurd, Ruth S.1  Hoosein, Naseema M.1  | |
[1] Medical Sciences Program and Department of Chemistry, Indiana University, Bloomington, IN 47405, USA | |
关键词: Glucagon-like peptide I; Glucagon-like peptide 2; Glucagon; cAMP; Pituitary; Hypothalamus; Liver plasma membrane; GLP-1; glucagon-like peptide 1; GLP-2; glucagon-like peptide 2; | |
DOI : 10.1016/0014-5793(84)81245-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [125I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP-1 and GLP-2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30–50 pM concentrations of each peptide elicited half-maximal adenylate cyclase stimulation. Our data suggest that GLP-1 and GLP-2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution.
【 授权许可】
Unknown
【 预 览 】
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RO201912020286129ZK.pdf | 342KB | download |