Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

FEBS Letters

Holmuhamedov, Ekhson L.²  Sidash, Sergueï S.¹  Ichas, François¹  Mazat, Jean-Pierre¹  Jouaville, Laurence S.¹ 

[1] Groupe d'Étude des Systèmes Biologiques Intégrés, D(BM)2, Université Bordeaux II, 33076 Bordeaux Cedex, France;Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 142292 Pushchino, Russian Federation

关键词: Calcium-induced calcium release;    Mitochondrion;    Permeability transition pore;    Cyclosporin A;    Cell calcium signalling;    Inositol triphosphate;    CICR;    calcium-induced calcium release;    mCICR;    mitochondrial calcium-induced calcium release;    mPTP;    mitochondrial permeability transition pore;    InsP3;    inositol triphosphate;    ER;    endoplasmic reticulum;    Cys A;    cyclosporin A;    PSC 833;    SDZ PSC 833;    TPP+;    tetraphenylphosphonium;    Ant A;    antimycin A;   

DOI  :  10.1016/0014-5793(94)00615-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report reversible Ca²⁺-induced Ca²⁺ release from mitochondria, which takes the form of Ca²⁺ spikes. Mitochondrial Ca²⁺ spiking is an all-or-none process with a threshold dependence on both the frequency and the amplitude of the Ca²⁺ pulses used as stimuli. This spiking relies on the transient operation of the mitochondrial permeability transition pore, and is initiated — in a threshold-dependent manner — with inositol-triphosphate-mediated Ca²⁺ responses in permeabilized cells. Evidence that mitochondrial Ca²⁺-induced Ca²⁺ release contributes to inositol-triphosphate-mediated Ca²⁺ responses in intact cells is also reported.

【 授权许可】

Unknown