Parallel changes in Glut 4 and Rab4 movements in two insulin‐resistant states

FEBS Letters

Cormont, Mireille¹  Tanti, Jean-François¹  Le Marchand-Brustel, Yannick¹  Ricort, Jean-Marc¹  Van Obberghen, Emmanuel¹ 

[1] Institut National de la Santé et de la Recherche Médicale, INSERM U 145, Faculté de Médecine, Avenue de Valombrose, 06107 Nice Cedex 02 France

关键词: Glut 4 translocation;    Rab4;    Insulin effect;    Adipocyte;    3T3-L1 adipocyte;    Diabetes;   

DOI  :  10.1016/0014-5793(94)00510-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Insulin-induced Glut 4 and Rab4 movements were studied in two insulin-resistant states. In adipocytes from streptozotocin diabetic rats, the amount of Glut 4 was decreased by 60%. The remaining Glut 4 molecules were translocated in response to insulin, and in parallel, Rab4 left the intracellular compartment. In contrast, in 3T3-L1 adipocytes rendered insulin-resistant by a prolonged insulin treatment, both Rab4 and Glut 4 remained in the intracellular compartment following an acute insulin stimulation. Those results illustrate a similar behavior of Glut 4 and Rab4 in two situations where insulin resistance results from different mechanisms, and add further support for a role of Rab4 in Glut 4 transiocation.

【 授权许可】

Unknown