Lipopolysaccharide increases resistin gene expression in vivo and in vitro

FEBS Letters

Chen, Chia-Ying³  Lu, Shao-Chun²  Hsu, Shu-Ching²  Shieh, Wei-Yeong²  Chen, Hui-Ling¹ 

[1]Hepatitis Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan

[2]Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, Taipei 100, Taiwan

[3]Department of Agricultural Chemistry, College of Agriculture, National Taiwan University, Taipei, Taiwan

关键词: Resistin;    Lipopolysaccharide;    Inflammation;    Adipocyte;    Monocyte;   

DOI  :  10.1016/S0014-5793(02)03450-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In this study, we tested whether lipopolysaccharide (LPS) induced resistin expression in rats. The results show that resistin mRNA levels in white adipose tissue and white blood cells were increased by LPS treatment. LPS also increased resistin mRNA levels in 3T3-L1 adipocytes and human peripheral blood monocytes. The results suggest that resistin is involved in insulin resistance and probably in other inflammatory responses.

【 授权许可】

Unknown