Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

NEUROBIOLOGY OF AGING

卷:66

Article

Augustin, Hrvoje^1,2  McGourty, Kieran^3,5  Allen, Marcus J.⁴  Adcott, Jennifer²  Wong, Chi Tung²  Boucrot, Emmanuel³  Partridge, Linda^1,2 

[1] Max Planck Inst Biol Ageing, Cologne, Germany

[2] UCL, Inst Hlth Ageing & GEE, Gower St, London WC1E 6BT, England

[3] Dept Struct & Mol Biol, London, England

[4] Univ Kent, Sch Biosci, Canterbury, Kent, England

[5] Univ Limerick, Bernal Inst, Limerick, Ireland

关键词: Aging;    Drosophila;    Giant Fiber system;    Gao junctions;    Insulin signaling;    Proteasomal activity;    Recycling;    Rab4;    Rab11;   

DOI  :  10.1016/j.neurobiolaging.2018.02.027

来源: Elsevier

【 摘 要 】

The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging. (C) 2018 Elsevier Inc.

【 授权许可】

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